![]() In vivo dissection of Otx1 and Otx2 roles in brain development by using reciprocal knock-in mouse models: definition of extended functional equivalence between OTX1 and OTX2 proteins and the relevance of the Otx1 and Otx2 differential transcriptional control.Identification of an Otx gene-dosage dependent mechanism required for patterning of developing brain and proper positioning of midbrain-hindbrain isthmic organizer.Role of Otx1 in corticogenesis, pituitary functions and sense organs development.Role of Otx2 in the specification of rostral CNS (forebrain, midbrain and anterior hindbrain).Temporal map during gastrulation of the retinoic acid effect on development and patterning of murine brain.Combined expression analysis of Otx, Emx, Dlx and Otp during development and definition of brain segmentary identities.Isolation and expression analysis in murine embryos of Dlx5 and Dl圆, two murine homologues of the Drosophila Distal-less gene.Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp).Isolation of the murine homologs of the otd and ems homeobox containing genes and analysis of their expression during brain development.Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1).Expression analysis of the human Hox Complex in teratocarcinoma cells (N-tera2/D1) upon treatment with retinoic acid and the definition of temporal colinearity concept.Expression analysis of several Hox genes in human embryos.Isolation and identification of the structural organization of the human homeobox gene family (HOX Complex). ![]() Isolation and characterization of alternative messenger RNAs coding class I HLA genes.Identification of transcription and processing signals of ribosomal genes of D.Molecular and structural organization of the non-transcribed spacer (NTS) of ribosomal DNA of D.Role of unequal crossing-over in the evolution of ribosomal genes. ![]()
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